Dr. Budziszewski begins by turning his criticism on himself, examining the foundations of the nihilism of his early career. Describing the political effects of Original Sin, he shows how man's suppression of his knowledge of right and wrong corrupts his conscience and accelerates social collapse. The depraved conscience grasps at the illusion of "moral neutrality," the absurd notion that men can live together without a shared understanding of how things are. After evaluating the political devices, including the American Constitution, by which men have tried in the past to work around the effects of Original Sin, Dr. Budziszewski elucidates the pitfalls of contemporary communitarianism, liberalism, and conservatism.

The revenge of conscience is horrifically manifest today in abortion, euthanasia, and suicide, evils brought about by the pollution of good impulses such as pity, prudence, honor, and love. The way out of this confusion, he concludes, is Christianity, a once-prevalent faith whose troubling memory men now suppress along with their knowledge of the natural law. The political responsibility of Christians is somehow to stir up that memory and that knowledge, a daunting task in a world of sound bites and shouting matches.