This book addresses the question of mobility of sub-micron particles in tissues, complex bio-environments, and, specifically, in tumors. This area is profoundly connected with application of novel drug carriers in nano-medicine. The understanding of ...
limitations pertaining to nano-transport of both biological and bio-MEMs based carriers plays a fundamental role in targeted drug delivery, imaging or plants nutrition delivery to mention just a few fields that benefit from theoretical insights into the particle's nano-transport in biological tissues. The book provides both mesoscopic and macroscopic of descriptions of the Interstitial tissue matrix that plays a fundamental role in the nano-transport. There is a detailed description of the governing equations that provides a framework for relating the underlying tissue structure with basic flow parameters. One of the novel aspects, the book provides, is the modeling of turtuosity and its relation to the apparent diffusion. The book contains number of applications of the presented theory to specific tumor structures and variety of drug nano-carries with respect to their potential to deliver various drugs to cancerous cells. The book bridges aspects of nano-medicine with the related modeling and computational approaches to allow for computer aided design of drug nano-carriers in terms of their size, weight and materials properties to asses their applicability, delivery strategies, in the above mentioned fields of delivery, imaging and nutrition.
Number of pages: 500
Date of publication: 15/01/2012
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