Local Control of Microvascular Perfusion by Michael Davis, Michael Hill
Local Control of Microvascular Perfusion by Michael Davis, Michael Hill
Local Control of Microvascular Perfusion by Michael Davis, Michael Hill
Local Control of Microvascular Perfusion by Michael Davis, Michael Hill

Local Control of Microvascular Perfusion

by Michael Davis, Michael Hill
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Description
Local control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local blood flow, or autoregulation, and its underlying mechanisms have been a subject of considerable interest for over 100 years. Particular focus has been placed on the acute interaction of myogenic (pressure-induced) and metabolic (local production of vasodilator metabolites) parameters and how they interact with flow (shear stress)-dependent and conduction-based mechanisms to produce integrated local vascular network responses (for example, as seen during reactive and functional hyperemia). This monograph discusses each of these vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations.
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About this Edition

Language

English

Publication Date

Oct 1, 2012

Format

eBook

Number of Pages

148

ISBN-13

9781615044375